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An institute

affiliated to USI


Lymphoma and Genomics Research Program

Program Head: Francesco Bertoni, MD

The Lymphoma and Genomics Research Program comprises two groups of investigators with a common interest in basic and translational research on lymphoma and leukemias. Research focuses on the identification of factors sustaining the development of these diseases to better understand their biology and to improve the management of the patients via better and novel therapies and diagnostic approaches.

1. Bertoni Group – Lymphoma Genomics

  • Non-coding RNAs in B-cell lymphoma
  • Mechanism of resistance to anti-lymphoma agents
  • Development of new anti-lymphoma compounds and identification of biomarkers
  • Development of a microfluidic platform for real-time detection of SARS-CoV-2 virus

2. Rossi Group – Experimental Hematology

  • The genetics of marginal zone lymphomas
  • The biological mechanisms underlying residual disease persistence in chronic lymphocytic leukemia (IOSI-EMA-001 and SAKK 34/17 clinical trials)
  • The development of liquid biopsy as tool to monitor residual and chemoresistant disease in aggressive lymphomas (IOSI-EMA-003 trial)
  • The development and validation of prognostic models in chronic lymphocytic leukemia, follicular lymphoma and splenic marginal zone lymphoma (IOSI-EMA-004, IOSI-EMA-005 and clinical IELSG46 trials)