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IOR

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affiliated to USI

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Research topics - Circulating tumor DNA uncovers the genetic and clinical heterogeneity of classic Hodgkin lymphoma

Circulating tumor DNA (ctDNA) is a tumor-derived portion of total cell-free DNA circulating in blood. The experimental hematology group tested the clinical validity of ctDNA for baseline mutation profiling, residual tumor load quantification, and acquisition of resistance mutations in patients with lymphoma. Collectively, the results provide the proof of concept that ctDNA is useful for noninvasive monitoring of patients with lympho