Team - Prostate Cancer Biology Lab
Group Leader: Carbone Giuseppina, MD
Giuseppina Carbone graduated in Medicine in 1983 and completed the clinical specialization school in 1987 at the University of Medicine of Naples Federico II. From 1988, she was research fellow at Wake Forest University Medical Centre (Winston-Salem, NC, USA) in the Department of Physiology and Pharmacology. From 1994, she was post-doctoral research fellow and from 2001, Research Assistant Professor in the Laboratory of Cancer Genomics at the Hollings Cancer Centre of the Medical University of South Carolina (MUSC), Charleston, USA. In 2003 she joined the IOR in Bellinzona, as Group Leader of the Prostate Cancer Biology laboratory.
She is the author of over 80 scientific publications and her major contributions include:
- Identification of the role of the transcription factor ESE3/EHF as an oncosuppressor and regulator of prostate epithelial cell differentiation status.
- Study of the impact of the TMPRSS2:ERG fusion in prostate cancer progression and definition of the molecular mechanisms leading to ERG transcriptional activation .
- Identification of microRNAs regulated by ETS factors.
- Role of extracellular vesicles or exosomes in prostate cancer progression.