Functional Cancer Genomics Lab
Research focus
Cancer is driven by cardinal molecular alterations that activate driver genes. Driver alterations are not only essential to initiate tumorigenesis but are also required for tumor growth and therapy failure. This raises the possibility to target these alterations, opening more specific, therapeutic opportunities to treat cancer patients.
Our research group focuses on key drivers of prostate cancer with emphasis on advanced, castration-resistant disease and transcriptional regulations. We aim to explore the roles of these genes in tumorigenesis and resistance to hormonal therapies with the goal to develop new therapeutic avenues for patients suffering from prostate cancer. In addition, we develop a web-based resource to enable researchers to investigate prostate cancer from early to late-stage disease in an integrated manner (https://www.prostatecanceratlas.org) with the ultimate goal of predicting treatment responses.
