Publications - Lymphomagenesis
Relevant publications
- Yu C, Holloman M, Kim A, Chang Y, Meyer S, Holmes AB, Cai B, Mo T, Dreval K, Morin R, Bhagat G, Mullighan CG, Dalla-Favera R, Pasqualucci L. Differential Role of CREBBP Missense and Truncating Mutations in Germinal Center Development and Lymphomagenesis. Blood, 2026; 147(23):2713-2727. PMID: 41746257 PMCID: PMC13277655. DOI: 10.1182/blood.2025031181
- Bal E, Kumar R, Hadigol M, Holmes AB, Hilton LK, Loh JW, Dreval K, Wong JCH, Vlasevska S, Corinaldesi C, Soni RK, Basso K, Morin RD, Khiabanian H, Pasqualucci L*, Dalla-Favera R*. Super-enhancer hypermutation alters oncogene expression in B cell lymphoma. Nature, 2022: 607(7920):808-815. PMID:35794478. DOI: 10.1038/s41586-022-04906-8 (*equal contribution)
- Meyer SN, Scuoppo C, Vlasevska S, Bal E, Holmes AB, Holloman M, Garcia-Ibanez L, Nataraj S, Duval R, Vantrimpont T, Basso K, Brooks N, Dalla-Favera R, Pasqualucci L. Unique and shared epigenetic programs of the CREBBP and EP300 acetyltransferases in germinal center B cells reveal targetable dependencies in lymphoma. Immunity, 2019; 51(3):535-547. PMID:31519498. DOI: 10.1016/j.immuni.2019.08.006.
- Zhang J, Vlasevska S, Wells VA, Nataraj S, Antony AB, Duval R, Meyer SN, Mo T, Basso K, Brindle PK, Hussein S, Dalla-Favera R, Pasqualucci L. The CREBBP acetyltransferase is a haploinsufficient tumor suppressor in B cell lymphoma. Cancer Discovery, 2017; 7(3): 322-337. doi: 10.1158/2159-8290. PMID: 28069569. PMCID: PMC5386396; DOI: 10.1158/2159-8290.CD-16-1417.
- Zhang J, Dominguez-Sola D, Hussein S, Lee JE, Holmes AB, Bansal M, Vlasevska S, Mo T, Tang H, Basso K, Ge K, Dalla-Favera R, Pasqualucci L. Disruption of KMT2D perturbs germinal center B cell development and promotes lymphomagenesis. Nature Medicine 2015; 21(10): 1190-1198. PMID: 26366712. DOI: 10.1038/nm.3940
- Pasqualucci L*, Dominguez-Sola D, Chiarenza A, Fabbri A, Grunn A, Trifonov V, Kasper LH, Lerach S, Tang H, Ma J, Rossi D, Chadburn A, Murty VV, Mullighan CG, Gaidano G, Rabadan R, Brindle PK and Dalla-Favera R*. Inactivating mutations of acetyltransferase genes in B-cell lymphoma. Nature, 2011; 471(7337):189-195. PMID: 21390126; PMCID: PMC3271441. DOI: 10.1038/nature09730 (*corresponding authors)
- Challa-Malladi M, Lieu YK, Califano O, Holmes A, Bhagat G, Murty VV, Dominguez-Sola D, Pasqualucci L*, Dalla-Favera R*. Combined genetic inactivation of beta2-microglobulin and CD58 reveals frequent escape from immune recognition in diffuse large B cell lymphoma. Cancer Cell, 2011; 20(6): 728-740. PMID: 22137796. DOI: 10.1016/j.ccr.2011.11.006 (*equal contribution)
- Compagno M, Lim WK, Grunn A, Nandula SV, Brahmachary M, Shen Q, Bertoni F, Ponzoni M, Scandurra M, Califano A, Bhagat G, Chadburn A, Dalla-Favera R, Pasqualucci L. Mutations in multiple genes cause deregulation of the NF-B pathway in diffuse large B-cell lymphoma. Nature, 2009; 459(7247):717-721. PMID: 19412164; PMCID: PMC2973325. DOI: 10.1038/nature07968
- Pasqualucci L*, Bhagat G, Jankovic M, Compagno M, Smith P, Muramatsu M, Honjo T, Morse HC 3rd, Nussenzweig MC, Dalla-Favera R*. AID is required for germinal center-derived lymphomagenesis. Nature Genetics, 2008; 40:108-112. PMID: 18066064 DOI: 10.1038/ng.2007.35 (*corresponding authors).
- Pasqualucci L, Neumeister P, Goossens T, Nanjangud G, Chaganti RSK, Küppers R, Dalla-Favera R. Hypermutation of multiple proto-oncogenes in B-cell Diffuse Large Cell Lymphomas Nature, 2001; 412: 341-346. PMID: 11460166 DOI: 10.1038/35085588
